发明名称 Oligonucleotideo composição farmacêutica olignucleotideo quimérico processos para modular a expressão de PKC em células para detectar em uma amostra a presença de um gene PKC ou MRNA PKC para diagnosticar uma condição associada com PKC molécula de ácido nucleico isolada oligonucleotideo anti-sentido tendo 5 a 50 nucleotideos de comprinento sonda de polinucleotideos rocessos para detectar um gene codificando para PKCA humano em uma amostra para detectar o transcrito de MRNA longo de PKCA humano
摘要 New nucleic acid sequences are provided which encode 3' untranslated regions of human protein kinase C alpha . Compositions and methods are provided for the treatment and diagnosis of diseases associated with protein kinase C alpha . Oligonucleotides are provided which are specifically hybridizable with nucleic acid encoding PKC alpha . Methods of treating animals suffering from disease amenable to therapeutic intervention by modulating protein kinase C expression with an oligonucleotide specifically hybridizable with RNA or DNA corresponding to PKC are disclosed. Polynucleotide probes for PKC alpha are also disclosed.
申请公布号 BR9406931(A) 申请公布日期 1996.09.10
申请号 BR19949406931 申请日期 1994.07.08
申请人 ISIS PHARMACEUTICALS, INC. 发明人 C FRANK BENNETT;RUSSELL T BOGGS;NICHOLAS M DEAN
分类号 C12N15/09;A61K31/7088;A61K31/711;A61K31/712;A61K31/7125;A61K38/00;A61K48/00;A61P29/00;A61P35/00;A61P43/00;C07H21/00;C07H21/04;C07K14/705;C12N5/10;C12N9/12;C12N15/113;C12Q1/48;C12Q1/68;G01N33/15;G01N33/50;G01N33/53;G01N33/566;G01N33/573;G01N33/68;(IPC1-7):C12Q1/68 主分类号 C12N15/09
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