发明名称 |
Oligonucleotideo composição farmacêutica olignucleotideo quimérico processos para modular a expressão de PKC em células para detectar em uma amostra a presença de um gene PKC ou MRNA PKC para diagnosticar uma condição associada com PKC molécula de ácido nucleico isolada oligonucleotideo anti-sentido tendo 5 a 50 nucleotideos de comprinento sonda de polinucleotideos rocessos para detectar um gene codificando para PKCA humano em uma amostra para detectar o transcrito de MRNA longo de PKCA humano |
摘要 |
New nucleic acid sequences are provided which encode 3' untranslated regions of human protein kinase C alpha . Compositions and methods are provided for the treatment and diagnosis of diseases associated with protein kinase C alpha . Oligonucleotides are provided which are specifically hybridizable with nucleic acid encoding PKC alpha . Methods of treating animals suffering from disease amenable to therapeutic intervention by modulating protein kinase C expression with an oligonucleotide specifically hybridizable with RNA or DNA corresponding to PKC are disclosed. Polynucleotide probes for PKC alpha are also disclosed. |
申请公布号 |
BR9406931(A) |
申请公布日期 |
1996.09.10 |
申请号 |
BR19949406931 |
申请日期 |
1994.07.08 |
申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
C FRANK BENNETT;RUSSELL T BOGGS;NICHOLAS M DEAN |
分类号 |
C12N15/09;A61K31/7088;A61K31/711;A61K31/712;A61K31/7125;A61K38/00;A61K48/00;A61P29/00;A61P35/00;A61P43/00;C07H21/00;C07H21/04;C07K14/705;C12N5/10;C12N9/12;C12N15/113;C12Q1/48;C12Q1/68;G01N33/15;G01N33/50;G01N33/53;G01N33/566;G01N33/573;G01N33/68;(IPC1-7):C12Q1/68 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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