PRODUCTION OF BIPHENYL COMPOUND

摘要

PURPOSE: To obtain the subject compound useful as am important intermediate for angiotensin II angonistics in high yield using an inexpensive chlorine derivative by carrying out a reaction of an o-substituted halobenzene in the presence of an amine compound and a specific catalyst in an ether-based solvent. CONSTITUTION: A reaction of (D) an O-substituted halobenzene of formula II (A is a 3-9C dialkoxymethyl, a 3-SC saturated dioxo ring or cyano; Y is same as X) with (B) a zinc halide and (C) a p-tolylmagnesium halide of formula I (X is Cl or Br) is carried out in an ether-based solvent in the presence of (A) an amine compound (preferably N,N,N",N'-tetramethylethylenediamine, etc.) and either catalyst among Ni (O), Ni(II), Pd(O) and Pd(II) [preferably dichlorobis(triphenylphosphine)Ni(II)] at -10 to 80 deg.C to provide the objective compound of formula III e.g. 4-methyl-2'-[1-(2,5-dioxolany]biphenyl}.