| 摘要 |
<p>Cephalosporin derivatives of general formula (I) wherein R1 is hydrogen, lower alkyl, aralkyl, cycloalkyl, R3CO- or -C(R4R5)CO2R6; where R4 and R5 are each independently hydrogen or lower alkyl, or R4 and R5 taken together form a cycloalkyl group; R3 is hydrogen or lower alkyl and R6 is hydrogen, lower alkyl, lower alkenyl or a carboxylic acid protecting group. R2 is isobutyl, 2,2-dimethyl-propyl or cyclohexyl-methyl; n is 0, 1 or 2; X is CH or N; as well as readily hydrolyzable esters thereof, pharmaceutically acceptable salts of said compounds and hydrates of the compounds of formula (I) and of their esters and salts.</p> |
