TRANSGENIC ANIMALS AS MODEL OF PSORIASIS

摘要

A nucleic acid construct comprising a promoter capable of directing expression in the suprabasal cells of the epidermis and means to cause expression of an integrin subunit in the suprabasal cells. Preferably the means to cause expression of an integrin subunit is an integrin subunit coding sequence. A transgenic animal which expresses an alpha subunit and a beta subunit of integring in the suprabasal cells of the epidermis and methods for making the transgenic animals. A least some of the transgenic animals are useful models of human disease, especially psoriasis. A method of treating psoriasis comprising administering to the patient a compound which modulates integrin function.