The present invention provides a monoclonal anti-idiotype antibody 3H1 that escapes immune tolerance and elicits a specific immune response to CEA in mice, rabbits, monkeys, and patients with advanced CEA-associated disease. This invention also provides compositions which can be used in the detection or treatment of CEA-associated tumors mimics a specific epitope on carcinoembryonic antigen and a hybridoma that produces 3H1. 00000
申请公布号
WO9620219(A3)
申请公布日期
1996.09.06
申请号
WO1995US17105
申请日期
1995.12.28
申请人
UNIVERSITY OF KENTUCKY;CHATTERJEE, MALAYA;KOHLER, HEINZ;CHATTERJEE, SUNIL, K.;FOON, KENNETH, A.
发明人
CHATTERJEE, MALAYA;KOHLER, HEINZ;CHATTERJEE, SUNIL, K.;FOON, KENNETH, A.