发明名称 |
CLONING AND RECOMBINANT PRODUCTION OF CRF RECEPTOR(S) |
摘要 |
In accordance with the present invention, there are provided novel G-protein-coupled receptor proteins (CRF-R) characterized by having sufficient binding affinity for corticotropin releasing factor (CRF) such that concentrations of </= 10nM of CRF occupy >/= 50 % of the binding sites of said receptor protein. Nucleic acid sequences encoding such receptors, assays employing same, as well as antibodies derived therefrom, are also disclosed. Invention CRF-Rs can be employed in a variety of ways, such as, for example, in bioassays, for production of antibodies thereto, in therapeutic compositions containing such proteins and/or antibodies. 00000 |
申请公布号 |
WO9617934(A3) |
申请公布日期 |
1996.09.06 |
申请号 |
WO1995US15909 |
申请日期 |
1995.12.06 |
申请人 |
THE SALK INSTITUTE FOR BIOLOGICAL STUDIES |
发明人 |
PERRIN, MARILYN, H.;CHEN, RUOPING;LEWIS, KATHY, A.;VALE, WYLIE, W., JR.;DONALDSON, CYNTHIA, J.;SAWCHENKO, PAUL |
分类号 |
G01N33/53;A61K38/00;C07K14/72;C07K16/28;C12N15/09;C12N15/12;C12P21/02;C12Q1/68;G01N33/566;(IPC1-7):C12N15/12;G01N33/68 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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