METHOD FOR IMMOBILIZING LIGANDS OR COMPOUNDS HAVING LIGANDS BONDED THERETO

摘要

A method for immobilizing a ligand by the use of a carrier prepared by reacting a solvent-insoluble carrier having aldehyde groups with a compound of general formula (a), by which a ligand or a compound having a ligand bonded thereto can efficiently and specifically be reacted with the aldehyde group of the carrier at a specific site to form a stable bond wherein: X is -S- or -O-; R<1>, R<2> and R<6> are each hydrogen or C1-C4 alkyl; R<3> is hydrogen or a substituent of general formula (a) wherein the atoms adjacent to the nitrogen atom have no unsaturated bond; R<4>, R<5> and R<7> are each an arbitrary substituent with the proviso that only one structural skeleton moiety of the formula: HX-C-C-NHR<3> or HX-C-C-C-NHR<3> (wherein X and R<3> are each as defined above) must be contained in the molecule.