摘要 |
Amplifying sequences, vectors comprising these sequences and their uses in compositions for the expression of nucleotide sequences in transfected cells, therapeutic and vaccine applications.Amplifying sequences showing a homology of at least 90% with the following SEQ ID N° 1 sequence:TCTATAAATA X1X2X3GC Y1Y2Y3GG TATTTGGGGT TGGCAGCTGT T in which:X1, X2 and X3 may independently represent respectively C or G, C or G, and C or AY1, Y2 and Y3 may independently represent respectively T or C, C or G, and T or C.Such sequence may included in a sequence or expression vector containing in addition a sequence coding for a protein and a promoter.Such sequences allow very strong amplification of the transcription of the gene coding for the protein. |