PHOSPHONO SUBSTITUTED TETRAZOLE DERIVATIVES AS ECE INHIBITORS

摘要

The N-phosphonomethyl substituted compounds of formula (I) and tautomers thereof wherein R0 represents a group of formula (Ia); R and R' represent independently hydrogen, carbocyclic aryl, 6-tetrahydronaphthyl, 5-indanyl, a-(trichloromethyl, carboxyl, esterified carboxyl or amidated carboxyl) substituted-(lower alkyl or aryl-lower alkyl), acyloxymethyl optionally monosubstituted on methyl carbon by lower alkyl, by C5-C7-cycloalkyl, by aryl or by aryl-lower alkyl; R1 represents phenyl, or phenyl substituted by lower alkyl, lower alkoxy, halogen or trifluoromethyl; or R1 represents thienyl or furanyl optionally substituted by lower alkyl; or R1 represents hydrogen; R2 and R4 represent hydrogen, lower alkyl, hydroxy, lower alkoxy, halogen or trifluoromethyl; n is 0, 1 or 2; and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising said compounds can be used in a method of the treatment of pulmonary hypertension, cerebral ischemia, subarachnoid hemorrhage, renal failure, atherosclerosis, cerebral vasospasm, arterial hypertrophy, restenosis, arrhythmia and myocardial infarction, endotoxic shock, preclampsia, diabetes, and Raynaud's disease.