| 摘要 |
PCT No. PCT/GB96/00352 Sec. 371 Date Mar. 30, 1998 Sec. 102(e) Date Mar. 30, 1998 PCT Filed Feb. 15, 1996 PCT Pub. No. WO96/25427 PCT Pub. Date Aug. 22, 1996This invention is directed to peptide inhibitors of serine proteases, espcecially thrombin, in which the P1-P2 natural amide linkage is replaced by another bond. Exemplary thrombin inhibitors have the formula: X-(aa3)-(aa2)- psi -(aa1)-Z wherein X is H or a substituent on the N-terminal amino group, aa3 is a hydrophobic amino acid, aa23 is Pro, aa1 is Arg or an Arg analgoue, Z is -COOH or a heteroatom acid group and psi is a non-amide linkage. |
