发明名称 Prepn. of eburnamenine-14-carboxylic acid - by allylic oxidn of eburnamenine-14-methanol catalysed by nickel peroxide, useful e.g. as vasodilator
摘要 The process comprises production of (3-alpha, 16-alpha)-eburno adenine-14-carboxylic acid to formula I from compound (3,16)-eburno aminine -14-methanol of formula II. This is based on an allyl oxidation reaction catalysed by nickel peroxide, with high yield in a simple installation. - The reaction is based on the following synthesis scheme, with advantages in production of derivative also acting as dilating agent.
申请公布号 ES2001320(A6) 申请公布日期 1988.05.01
申请号 ES19860003006 申请日期 1986.11.12
申请人 COVEX, S.A. 发明人 CALVO MONDELO FERNANDO;MANRESA FERRERO M TERESA
分类号 A61K31/475;C07D461/00;(IPC1-7):C07D461/00 主分类号 A61K31/475
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