发明名称 |
Prepn. of eburnamenine-14-carboxylic acid - by allylic oxidn of eburnamenine-14-methanol catalysed by nickel peroxide, useful e.g. as vasodilator |
摘要 |
The process comprises production of (3-alpha, 16-alpha)-eburno adenine-14-carboxylic acid to formula I from compound (3,16)-eburno aminine -14-methanol of formula II. This is based on an allyl oxidation reaction catalysed by nickel peroxide, with high yield in a simple installation. - The reaction is based on the following synthesis scheme, with advantages in production of derivative also acting as dilating agent.
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申请公布号 |
ES2001320(A6) |
申请公布日期 |
1988.05.01 |
申请号 |
ES19860003006 |
申请日期 |
1986.11.12 |
申请人 |
COVEX, S.A. |
发明人 |
CALVO MONDELO FERNANDO;MANRESA FERRERO M TERESA |
分类号 |
A61K31/475;C07D461/00;(IPC1-7):C07D461/00 |
主分类号 |
A61K31/475 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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