发明名称 |
DNA encoding precursor of interleukin-1 beta converting enzyme - related cysteine proteinase III (ice rel-III) |
摘要 |
A complementary DNA (cDNA) encoding full length form of ICErel-III is identified, sequenced and isolated. The cDNA is cloned into expression vectors for expression in recombinant hosts. The cDNA is useful to produce recombinant full length ICErel-III. The cDNA and the recombinant ICErel-III protein derived therefrom are useful in diagnostic kits, laboratory reagents and assays. The cDNA and the recombinant ICErel-III protein may be used to identify compounds that affect ICErel-III function, inflammation and cell apoptosis. ICErel-III function, inflammation and cell apoptosis may also be modulated by ICErel-III antisense or gene therapy.
|
申请公布号 |
US5552536(A) |
申请公布日期 |
1996.09.03 |
申请号 |
US19940224930 |
申请日期 |
1994.04.08 |
申请人 |
MERCK FROSST CANADA, INC. |
发明人 |
NICHOLSON, DONALD W.;ALI, AMBEREEN;MUNDAY, NEIL A.;VAILLANCOURT, JOHN P. |
分类号 |
G01N33/53;A61K38/00;A61K38/46;A61K48/00;A61P9/00;A61P25/00;A61P25/28;A61P31/04;A61P35/00;A61P37/00;A61P43/00;C07H21/04;C07K16/40;C12N1/19;C12N1/21;C12N5/10;C12N9/64;C12N15/09;C12N15/57;C12Q1/37;C12Q1/68;C12R1/91;(IPC1-7):C07H21/02;C12N15/70 |
主分类号 |
G01N33/53 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|