Fremgangsmåde til diagnose af ikke-insulinafhængig diabetes mellitus

摘要

PCT No. PCT/EP92/00949 Sec. 371 Date Nov. 21, 1994 Sec. 102(e) Date Nov. 21, 1994 PCT Filed Apr. 30, 1992 PCT Pub. No. WO92/19769 PCT Pub. Date Nov. 12, 1992To diagnose non-insulin dependent diabetes mellitus or a genetically conditioned disposition thereto, examinations are made of tissue cells, especially skeletal muscle cells, from the person concerned for the presence of the human insulin receptor type B (HIR-B). This examination is preferably conducted with the aid of specific oligonucleotides as primers in a PCR amplification reaction of cDNA obtained from tissue RNA which enables a distinction to be made between HIR-A and HIR-B RNA.