| 摘要 |
<p>PURPOSE: To obtain a new condensed pyridazine compound useful for preventing and treating cardio-vascular insufficiency, having excellent inhibitory action on CGMP-PDE(cyclic GMP phosphodiesterase), high watersolubility, excellent absorption in body and low toxicity. CONSTITUTION: This condensed pyridazine-based compound is shown by formula I (ring C is a 5- to 6-membered ring which may contain a hetero atom; (n) is an integer of 0 or 1-4; R<1> is a halogen, nitro, cyano, etc.,; A is H, a halogen, an aryl, etc.; X is a group of the formula N, etc.; Y is group of the formula CO, etc.; an alternate long and short dash line is a double bond or a single bond with the proviso that a case where (n) is 0 is omitted when the ring C is a benzene ring) or its pharmacologically permissible salt. The most preferable example is a compound of formula II. The compound of formula I, for example, is obtained by halogenating a 1,4-phthalazinedione derivative.</p> |
