NOVEL PROCESS FOR PREPARING CRYSTALLINE HYDRATE OF CEPHALOSPORIN

摘要

The crystalline cephtazidim bishydroiodide monohydrate of formula(I') are prepared by reacting 3-acetoxymethyl cephalosporin compd. of formula(II) with pyridine in the presence of trimethyliodosilane of formula(III), and reacting compd. of formula(I') with 2-3eq. base. In formula, R1,R2 and R3 are alkyl group of C1-C4.