METHODS AND COMPOSITIONS FOR ADMINISTERING GENE THERAPY VECTORS
摘要
A method of reducing immune response during gene therapy is provided which involves co-administration of the viral vector bearing a therapeutic transgene and a selected immune modulator capable of inhibiting the formation of neutralizing antibodies and/or CTL elimination of the vectors upon repeated administration.
申请公布号
WO9626285(A2)
申请公布日期
1996.08.29
申请号
WO1996US03035
申请日期
1996.02.23
申请人
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY;WILSON, JAMES, M.;YANG, YIPING;TRINCHIERI, GIORGIO
发明人
WILSON, JAMES, M.;YANG, YIPING;TRINCHIERI, GIORGIO