ISOLATED DNA SEQUENCE FOR A NOVEL MACROPHAGE RECEPTOR WITH A COLLAGENOUS DOMAIN AND THE POLYPEPTIDE CHAIN ENCODED BY SUCH A SEQUENCE

摘要

The present invention is directed to processes for isolating and identifying the nucleotide sequence of a gene for a novel macrophage receptor with collagenous structure, termed "MARCO". The new macrophage receptor with a collagenous domain binds gram positive and negative bacteria and acetylated LDL. Moreover, the invention relates to the nucleotide sequence for MARCO identified by the process of the invention and the isolated and purified polypeptide chain encoded by such a sequence.