| 摘要 |
<p>Compounds, including compositions and methods of making and using these compounds for treating retroviral infections, are provided according to formula (G-1), wherein M is O or NH; Z is O, NH or S; R?240, and R250¿ are each H, C¿1-10? alkyl, C1-10 aryl, alkyl, amide, or CH2COOR?260¿, where R260 is C¿1-10? alkyl or acyl; R?200, R210, R220 and R230¿ are each H, halogen, hydroxyl, NH¿2?, NH-alkyl, N-(alkyl)2, O-alkyl, O-acyl, COCF3, OCF3 or CH2COO NH-alkyl; or R?200 and R210¿ form C¿5?-C10 cyclo or heterocyclo optionally substituted with one or more of halogen, hydroxyl, NH2, NH-alkyl, N-(alkyl)?2¿, O-acyl, O-alkyl, CO, CF¿3?, OCF3 or CH2 COONH-alkyl; wherein C3 and C4 can be bound by a single or double bond; configurations at 3' or 4' can be (R) or (S); and R?240 and R250¿ are either cis-β or cis-α, or trans-3'-α or trans-3'-β oriented. Stereoselectivity can be enhanced by preparing these compounds by catalytic asymmetric dihydroxylation.</p> |
