| 摘要 |
PCT No. PCT/DE95/01690 Sec. 371 Date May 29, 1997 Sec. 102(e) Date May 29, 1997 PCT Filed Nov. 29, 1995 PCT Pub. No. WO96/16594 PCT Pub. Date Jun. 6, 1996A process and a device for determining the cerebral blood flow, and the intracerebral blood volume are described. After injection into the bloodstream of a predefined quantity of a double indicator, arterial and venous measurements of the indicator dilution curves resulting in the blood stream are carried out. A dye solution differing in its temperature from the body temperature serves as a double indicator, in which heat or cold constitute a highly diffusible indicator component, and dye, preferably indo cyanine green ICG, constitute an intravascular indicator component. The cerebral blood flow CBF is calculated from the ratio of a distribution coefficient lambda therm of the highly diffusible indicator component therm between blood and cerebral tissue and the mean transit time mtttherm of the highly diffusible indicator component therm through the brain. The intracerebral blood volume ICBV is calculated from the product of cerebral blood flow CBF and the mean transit time mttICG of the intravascular indicator component ICG. |
