MODULATORS OF ANCHORING PROTEIN FUNCTION MODULATORS OF ANCHORING PROTEIN FUNCTION
摘要
The present invention provides compositions and methods useful for isolating calcineurin as well as inhibiting calcineurin activity. The compositions are peptides that contain regions that are homologous to calcineurin-binding regions of AKAP 79. Also provided are methods for determining if a cell contains a calcineurin-binding and PKA-binding anchoring protein that are useful for identifying additional proteins that bind both calcineurin and PKA. Another aspect of the present invention is methods for enhancing expression of interleukin 2 by T cells.
申请公布号
WO9616172(A3)
申请公布日期
1996.08.29
申请号
WO1995US16039
申请日期
1995.11.22
申请人
ICOS CORPORATION;THE STATE OF OREGON, ACTING BY AND THROUGH THE ORE