| 摘要 |
Compounds, including compositions and methods of making and using these compounds for treating retroviral infections, are provided according to formula (G-1), wherein M is O or NH; Z is O, NH or S; R<240>, and R<250> are each H, C1-10 alkyl, C1-10 aryl, alkyl, amide, or CH2COOR<260>, where R<260> is C1-10 alkyl or acyl; R<200>, R<210>, R<220> and R<230> are each H, halogen, hydroxyl, NH2, NH-alkyl, N-(alkyl)2, O-alkyl, O-acyl, COCF3, OCF3 or CH2COO NH-alkyl; or R<200> and R<210> form C5-C10 cyclo or heterocyclo optionally substituted with one or more of halogen, hydroxyl, NH2, NH-alkyl, N-(alkyl)<2>, O-acyl, O-alkyl, CO, CF3, OCF3 or CH2 COONH-alkyl; wherein C3 and C4 can be bound by a single or double bond; configurations at 3' or 4' can be (R) or (S); and R<240> and R<250> are either cis- beta or cis- alpha , or trans-3'- DOLLAR g(a) or trans-3'- DOLLAR g(b) oriented. Stereoselectivity can be enhanced by preparing these compounds by catalytic asymmetric dihydroxylation.
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