发明名称 |
ANTAGONISTS OF INTERLEUKIN-15 |
摘要 |
Antagonists of mammalian interleukin-15 ("IL-15") are disclosed and include muteins of IL-15 and modified IL-15 molecules that are each capable of binding to the IL-15R alpha -subunit and that are incapable of transducing a signal through either the beta - or gamma -subunits of the IL-15 receptor complex. Also included are monoclonal antibodies against IL-15 that prevent IL-15 from effecting signal transduction through either the beta - or gamma -subunits of the IL-15 receptor complex. Methods of treating various disease states are disclosed, including treating allograft rejection and graft-versus-host disease.
|
申请公布号 |
WO9626274(A1) |
申请公布日期 |
1996.08.29 |
申请号 |
WO1996US02520 |
申请日期 |
1996.02.21 |
申请人 |
IMMUNEX CORPORATION |
发明人 |
GRABSTEIN, KENNETH, H.;PETTIT, DEAN, K.;PAXTON, RAYMOND, J. |
分类号 |
C12N15/09;A61K38/00;A61K39/395;A61K47/48;A61P37/06;C07K14/54;C07K16/24;C07K16/42;C07K19/00;C12N1/19;C12N15/24;C12P21/02;C12P21/08;C12R1/865;(IPC1-7):C12N15/24;A61K38/20;C12N1/21 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|