Nanoparticulate diagnostic dimers as x-ray contrast agents for blood pool and lymphatic system imaging

摘要

This invention relates to methods of x-ray diagnostic imaging the blood pool, liver, spleen and/or lymph system of a mammal comprising administering a contrast effective amount of a succinic acid derivative disubstituted with benzoic acid residue as a contrast agent having the structure: Structure I R1 and R2 are alkyl of from 2 to 18 carbon atoms; Ar is R3 is selected from the group consisting of NCH2, NHAc, and wherein R is an alkyl of 1 to 10 carbon atoms; R6 is H, alkyl of from 1 to 4 carbon atoms; R4 is selected from the group consisting of 10 carbon atoms. R5 is alkyl having 1 to 18 carbon atoms and Ac is acyl. This invention further relates to novel contrast agents having the above structure wherein R1 and R2 are C2H5, to x-ray contrast compositions comprising such agents, and to method of x-ray diagnostic imaging utilizing such agents.