发明名称 |
Method for reducing filtrate waste in a manufacturing process of a pharmaceutical product containing benzalkonium chloride |
摘要 |
A method for reducing filtrate waste in a manufacturing process of a pharmaceutical product containing benzalkonium chloride as a preservative generally includes the steps of mixing the non-benzalkonium chloride components with benzalkonium chloride to formulate the product and thereafter sterilizing the product by passing same through a microfiltration membrane. In processes in which the product has a time dependent benzalkonium chloride content due to benzalkonium chloride adsorption on a microfiltration membrane, an amount of benzalkonium chloride wasted can be reduced by maintaining a selected temperature of the microfiltration membrane and the product therein.
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申请公布号 |
US5550163(A) |
申请公布日期 |
1996.08.27 |
申请号 |
US19940285079 |
申请日期 |
1994.08.03 |
申请人 |
ALLERGAN, INC. |
发明人 |
DING, SHULIN;PALLO, ROBERT J.;TIEN, WALTER L.;OLEJNIK, OREST |
分类号 |
A61K9/00;(IPC1-7):A61K31/14 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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