| 摘要 |
FIELD: organic chemistry. SUBSTANCE: product: compound of the formulawhere R - hydrogen, hydroxy, C-C-alkoxy, group of the formula -O-C(O)-Rwhere R- hydrogen, C-C-alkyl optional substituted with amino-, halide- carbonyl, C-C-alkoxycarbonyl, C-C-alkanoylhydroxy-, carbamoyl and/or aryl groups; or Rmeans C-C-alkenyl optional substituted with aryl group; or Rmeans C-C-cycloalkyl; or Rmeans aryl optional substituted with hydroxy-, C-C-alkyl and/or halide-groups; or Rmeans -O-aryl in which aryl is optional substituted with hydroxy-C-C-alkyl, C-C-alkoxy and/or halide-groups; or R means group of the formula -O-SO-Rwhere Rcan be C-C-alkyl or aryl optional substituted with C-C-alkyl; or R means carbamoylhydroxy-group where nitrogen can be substituted with C-C-alkyl at a single or two cases; or R means group of the formula -O--O-C(O)R-O-C-C-alkyl) where Rmeans bond or C-C-alkanediyl; Rmeans halide-group, C-C-alkyl, C-C-alkyl substituted with C-C-alkyl, free or substituted C-C-cycloalkyl or free or substituted C-C-cycloalkenyl; Rmeans O or CH; Rmeans CHor ; Rmeans, CHor bond; and Rmeans imino-group, nitrilo-group optional substituted with C-Cat a single or two cases; or N-heterocyclic ring that is optional has other heteroatom taken from N, O or S in indicated ring; or its pharmaceutically acceptable salt or solvate, and invention relates to new use of indicated compound also. Synthesized compounds were used to decrease cholesterol concentration in serum blood and administrated at effective doses. EFFECT: improved method of synthesis. |
