| 摘要 |
<p>Spiroalkylamine derivatives and their salts have a general formula (I), wherein R1 is hydrogen, substituted or unsubstituted C1-C20 alkyl, substituted or unsubstituted benzyl, formyl, substituted or unsubstituted C1-C5 alkylcarbonyl, substituted or unsubstituted benzoyl, substituted or unsubstituted C1-C5 alkoxycarbonyl, substituted or unsubstituted benzyloxycarbonyl, substituted or unsubstituted C1-C5 alkylsulfonyl, or substituted or unsubstituted benzenesulfonyl; R2 is hydrogen or methyl substituted at the position of 4 or 6; R3 is hydroxy, hydroxymethyl, carboxy, C1-C4 alkoxy, C2-C5 alkoxymethyl, C2-C5 acyloxy, C3-C6 acyloxymethyl, methanesulfonyloxy, methanesulfonyloxymethyl, p-toluenesulfonyloxy, p-toluenesulfonyloxymethyl, cyanato, C2-C6 alkoxycarbonyl, azidocarbonyl, C1-C8 alkyl, C1-C5 alkoxycarbonyl, aminocarbonyl substituted or unsubstituted benzyl or -(CH2)m-NR4R5, where m is 0 or 1; R4 is hydrogen, C1-C4 alkanoyl or benzoyl; and R5 is hydrogen, C1-C4 -alkyl, nitrogen protective group degradable in a living body, n is 1 or 2, diastereomers may be (1,3)-R,S, (1,3)-R,R, (1,3)-S,S or (1,3)-S,R.</p> |
