FEEDBACK CONTROLLED DRUG DELIVERY SYSTEM

摘要

A feedback controlled drug delivery system includes automated blood sampling and analysis and dosing of the patient. Automated sampling is performed by direct analysis of patient blood, such as for measurement of its coagulation state. A novel manifold includes a fluid input port, a patient port adapted to output fluid and to receive a blood sample from the patient, and a fluid pathway connecting the fluid port and the patient port. A sample line is connected to the fluid pathway to provide the sample to an analyzer. In one aspect of this invention, the sample is forced through the sample line by isolating the patient port, such as by a valve, and non-drug fluid is forced into the manifold causing the blood to cross through the sample line. In another embodiment, an integrated assembly includes an integrated peristaltic pump, valve assembly, selectively movable actuator and integrated waste container. In one aspect, the peristaltic pump permits retraction of the rollers away from the inner circumference of the pump, so as to reduce deformation of the peri-pump tube and to permit sterilization.