| 摘要 |
<p>A process for enhancing the security of implantable surgical devices secured to bone tissue comprising implanting in bone tissue a surgical device with a biocompatible adhesive and/or sealant selected from the group consisting of: (a) a material made from monomers of the formula: CHR<1>=CX<1>Y<1> wherein X<1> and Y<1> are each strong electron withdrawing groups, and R<1> is hydrogen or, provided that X<1> and Y<1> are both cyano groups, a C1-C4 alkyl group; (b) a semi-crystalline aliphatic poly(ester) of the formula: Ä-O-R<11>-C(O)-ÜY, wherein R<11> is selected from the group consisting of -CR<12>H-, -(CH2)3-O-, -CH2-CH2-O-CH2-, CR<12>H-CH2, - (CH2)4-, -(CH2)z-O-C(O)- and -(CH2)z-C(O)-CH2-; R<12> is hydrogen or methyl; z is an integer in the range of from 1 to 7 and y is an integer in the range of from about 10 to about 20,000; and (c) a slurry of water and a calcium containing compounds with the general formula: M<2+>10-nN<1+>2n(WO4<3->)6mU<2-> where n is an integer from 1 to 10, and m is 2 when x is 1, or m is 1 when x is 2, M and N are alkali or alkaline earth metals; WO4 is an acid radical and W is phosphorus, vanadium, sulfur, silicon, or is substituted in whole or part with carbonate (CO3<2->); and U is a halide, hydroxide, or carbonate; provided in an amount effective to increase the amount of force necessary to remove the implanted surgical device. Additionally provided is a surgical device that is at least partially coated with at least one biocompatible adhesive and/or sealant.</p> |
