| 摘要 |
PCT No. PCT/GB96/00179 Sec. 371 Date Jul. 22, 1997 Sec. 102(e) Date Jul. 22, 1997 PCT Filed Jan. 29, 1996 PCT Pub. No. WO96/23785 PCT Pub. Date Aug. 8, 1996A class of 1,4-disubstituted piperazine derivatives, further substituted on one of the carbon atoms of the piperazine ring, are selective agonists of 5-HT1-like receptors, being potent agonists of the human 5-HT1D alpha receptor subtype whilst possessing at least a 10-fold selective affinity for the 5-HT1D alpha receptor subtype relative to the 5-HT1D beta subtype; they are therefore useful in the treatment and/or prevention of clinical conditions, in particular migraine and associated disorders, for which a subtype-selective agonist of 5-HT1D receptors is indicated, while eliciting fewer side-effects, notably adverse cardiovascular events, than those associated with non-subtype-selective 5-HT1D receptor agonists. |
