| 摘要 |
<p>A process for producing intermediate compounds 2-deoxy 2,2-difluoro- beta -D-ribo-pentopyranose (III) from 3,3-difluoro-4,5,6- trihydroxy-5,6-O-(1-ethylpropylidene)hexene (I). The process of preparing intermediate compound (I) involves reacting D-glyceraldehyde pentanide with an organometallic complex of 3-bromo-3,3-difluoropropene. The process of preparing intermediate compound (III) involves ozonolysis and then hydrolysis. The intermediate compounds (I) and (III) are used in the preparation of 2'-deoxy-2',2'-difluorocytidine which is an antiviral agent. <CHEM></p> |
