| 发明名称 |
Expression of recombinant proteins in attenuated bacteria |
| 摘要 |
The invention concerns a vaccine comprising an attenuated Salmonella bacterium which contains a nirB promoter operably linked to a DNA sequence encoding a heterologous protein. The nirB promoter directs expression of the heterologous protein in a host it is wished to vaccinate.
|
| 申请公布号 |
US5547664(A) |
申请公布日期 |
1996.08.20 |
| 申请号 |
US19940354776 |
申请日期 |
1994.12.12 |
| 申请人 |
BURROUGHS WELLCOME CO. |
发明人 |
CHARLES, IAN G.;CHATFIELD, STEVEN N.;FAIRWEATHER, NEIL F. |
| 分类号 |
A61K39/00;A61K39/02;A61K39/112;A61P31/04;C07K14/235;C07K14/33;C12N1/21;C12N15/09;C12N15/31;C12N15/70;C12N15/74;C12R1/01;C12R1/42;(IPC1-7):A61K39/08;A61K39/10 |
主分类号 |
A61K39/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
