发明名称 |
Kainate-binding human CNS glutamate receptors EAA3C and EAA3D, DNA encoding them, and expression of the DNA in transformed cells |
摘要 |
Neurotransmission by excitatory amino acids (EAAs) such as glutamate is mediated via membrane-bound surface receptors. DNA coding for one family of the kainate-binding type of EAA receptor, has now been isolated and the receptor protein characterized. Herein described are recombinant cell lines which produce the EAA receptor as a heterologous membrane-bound product. Disclosed is use of the cell lines as a tool for discovery of compounds which modulate EAA receptor stimulation.
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申请公布号 |
US5547855(A) |
申请公布日期 |
1996.08.20 |
申请号 |
US19950405392 |
申请日期 |
1995.03.15 |
申请人 |
ALLELIX BIOPHARMACEUTICALS INC. |
发明人 |
KAMBOJ, RAJENDER;ELLIOTT, CANDACE E.;NUTT, STEPHEN L. |
分类号 |
C07K14/435;C07K14/00;C07K14/705;C07K16/00;C07K16/28;C12N5/10;C12N15/09;C12N15/12;C12P21/02;C12R1/91;G01N33/53;G01N33/566;(IPC1-7):C12N15/12;C08L89/00 |
主分类号 |
C07K14/435 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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