发明名称 |
RIBOZYME ANALOGS RIBOZYME ANALOGS |
摘要 |
Disclosed are ribozyme analogs having the ability to endonucleolytically cleave a sequence of 3' to 5' linked ribonucleotides. The ribozyme analogs include a plurality of 3' to 5' covalently-linked nucleotides, and a rigid molecular linker having at least one non-nucleotidic molecule covalently linked to two of the nucleotides. Also disclosed are methods of preparing and utilizing the ribozyme analogs of the invention, and pharmaceutical formulations and kits containing such ribozyme analogs. |
申请公布号 |
WO9615240(A3) |
申请公布日期 |
1996.08.15 |
申请号 |
WO1995US14705 |
申请日期 |
1995.11.08 |
申请人 |
HYBRIDON, INC. |
发明人 |
GOODCHILD, JOHN;LEONARD, THOMAS, E. |
分类号 |
C12N15/09;A61K31/70;A61K38/00;A61K48/00;C07H21/02;C12N9/00;C12N15/113 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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