| 摘要 |
<p>The present invention is concerned with compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein =a1-a2=a3-a4= is a bivalent radical of formula (a): =N-CH=CH-CH=, (b): =CH-N=CH-CH=, (c): =CH-CH=N-CH=, (d): =CH-CH=CH-N=, wherein one or two hydrogen atoms can be substituted by halo, hydroxy, C1-6 alkyl or C1-6 alkyloxy; R1 is hydrogen or C¿1-6? alkyl; R?2¿ is hydrogen or C¿1-6? alkyl; R?3¿ is hydrogen or C¿1-6? alkyl; Alk?1¿ is C¿1-5? alkanediyl; Alk?2¿ is C¿2-15? alkanediyl; Q is a five- or six-membered heterocyclic ring containing at least one nitrogen atom or a radical of formula -C(NR?5R6)=C-R4¿ wherein R4 is hydrogen, cyano, aminocarbonyl or C¿1-6? alkyl; R?5¿ is hydrogen, C¿1-6? alkyl, C3-6 alkenyl or C3-6 alkynyl; R?6¿ is hydrogen or C¿1-6? alkyl; or R?5 and R6¿ taken together may form a bivalent radical of formula -(CH¿2?)4- or -(CH2)5-. Pharmaceutical compositions, preparations and use as a medicine are described.</p> |
