NEW MEDICAL FORMS WITH PROLONGED EFFECT APPLIED IN EYE MEDICINE AND THE METHOD FOR PREPARATION THEREOF

摘要

The invention pertains to new medical forms of pharmaceutics with prolonged effect applied in eye medicine, which are formed by a pregel or gel based on the copolymers of 2-(2-carboxybenzoyloxy)ethyl methacrylate with methacrylate comonomers selected from the group comprising methyl methacrylate and butyl methacrylate, the carboxyl groups of which are at least in part modified and/or neutralized with at least one pharmaceutically active substance and/or neutralized with Na<+> and/or K<+> ions and/or organic bases and which contains, if it is desired, encapsulated another pharmaceutically active substances. One of the methods for the preparation of these new medical forms consists in at least partial neutralization of functional carboxyl groups of the latex, based on the copolymers of 2-(2-carboxybenzoyloxy)ethyl methacrylate with methacrylate comonomers selected from the group comprising methyl methacrylate and butyl methacrylate, with a basic pharmaceutically active substance and/or sodium hydroxide and/or potassium hydroxide and/or organic bases. The scope of the invented solution comprises also further methods for the preparation of the medical forms according to the invention.