COMPOUND DELIVERY USING HIGH-PRESSURE IMPULSE TRANSIENTS

摘要

A method of increasing delivery of a compound from an exterior region (18) to an interior region of a cell (20) without causing substantial lethality to the cell. The method includes the steps of first providing the compound in the exterior region proximal to a member (12) of the cell (14), and then exposing the membrane to a time-dependent impulse transient characterized by a rise time and a magnitude. In this manner, the exposing step temporarily increases the permeability of the membrane, resulting in an increase in the diffusion of the compound from the exterior region to the interior (20) region thereby enhancing the delivery of the compound without causing substantial lethality to the cell.