Anreicherung von Enantiomeren und stereoselektive Herstellung von chiralen Aminen
摘要
Amines in which the amino group is on a secondary carbon atom which is chirally substituted can be enantiomerically enriched by the action of an omega-amino acid transaminase which has the property of preferentially converting one of the two chiral forms to a ketone. The process also can be used to stereoselectively synthesize one chiral form from ketones substantially to the exclusion of the other.
申请公布号
DE69025988(T2)
申请公布日期
1996.08.14
申请号
DE1990625988T
申请日期
1990.06.21
申请人
CELGENE CORP., WARREN, N.J., US
发明人
STIRLING, DAVID I., FANWOOD, NEW JERSEY 07023, US;ZEITLIN, ANDREW L., GREEN BROOK, NEW JERSEY 08812, US;MATCHAM, GEORGE W., BRIDGEWATER, NEW JERSEY, 08807, US