Neue Pyridyl- bzw. Pyridazinyl-Piperazinderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel

摘要

Compounds of formula (I), in which R<1> stands for hydrogen, lower alkyl, lower alkenyl, cycloalkyl, cycloalkenyl, a possibly substituted mono-or bi-cyclic aryl, a possibly substituted hetaryl, a possibly substituted aryl alkyl or one of the groups -OR<2>, -NR<3>R<4>, W stands for nitrogen or -CR<5>, X, Z independently of each other stands for nitrogen or -CH, and where W stands for a nitrogen atom, X must be the group -CH, A stands for a valency bond or the carbonyl group, B stands for a valency bond or a C1-C6 alkyl chain possibly substituted once or several times by lower alkyl or an OR<2> group, D stands for a valency bond, and, where X is a nitrogen atom, can also be the carbonyl group, A, B and D being unable to represent the valency bond simultaneously, R<2> stands for hydrogen, lower alkyl or aryl alkyl, R<3>, R<4> independently of each other stand for hydrogen or lower alkyl, or form a five- or six-membered heterocyclic ring together with the nitrogen atom to which they are linked, R<5> stands for hydrogen or a group OR<2>. The invention also relates to a process for the production of these compounds, and medicaments containing them for the treatment of diseases which are attributable to thromboembolic conditions.