Methods and compositions for lipidization of hydrophilic molecules

摘要

The invention provides uses of lipid-containing moieties in the manufacture of compounds for delivery of sulfhydryl group-containing compounds into mammalian cells. The sulfhydryl group-containing moieties are suitably peptides, proteins or oligonucleotides which contain or have been modified to contain sulfhdryl group. The lipid-containing moiety is conjugated to the sulfhydryl group-containing moiety via a disulphide linkage. Preferred lipid-containing moieties are described.