Aryl and heteroaryl macrolides having immunosuppressive activity

摘要

Aryl and heteroaryl macrolides of the general structural Formula I: <IMAGE> I have been prepared from suitable precursors by olefination at C-27. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases, the prevention of rejection of foreign organ transplants and/or related afflictions, diseases, and illnesses.