USE OF VWF-CONTAINING CONCENTRATE AS MEDICAL TREATMENT APPLIED BY COMBINING WITH ANTI-THROMBOTIC AND THROMBUS-DISSOLVING MEDICAL TREATMENT

摘要

PROBLEM TO BE SOLVED: To obtain a preparation acting as an alexipharmac for reducing the danger of hemorrhage caused by the administration of an antithrombotic medicine or a thrombolytic medicine and not impairing the antithrombotic or thrombolytic effect by using von Willebrand factor of soluble serum protein. SOLUTION: This preparation contains von Willebrand factor (vWF) or a fragment having the vWF activity as an active ingredient. An antithrombotic medicine capable of being combined with the preparation includes synthetic thrombin-inhibiting agents such as heparin or γ-hirudine. The thrombolytic medicine capable of being combined with the preparation and the antithrombotic medicine preferably comprises streptokinase, plasminogen activators, and their derivatives. The preparation is preferably administered, when or after the antithrombotic medicine is administered and lysed.