| 摘要 |
PURPOSE: To obtain a new peptide compound useful as an anti-cerebral infarct agent, an antiepileptic, a sedative, etc., showing inhibitory action on N type calcium channel, by culturing a bacterium beloinging to the genus Streptomyces, capable of producing A-53903A and B. CONSTITUTION: The new compound A-53903A and compound A-53903B are shown by formula I and by formula II, Respectively. The new compounds show inhibitory action on N type calcium channel and is useful as an anti-cerebral infarct agent, an antiepileptic, a sedative, etc. The new compounds are obtained by inoculating a bacterium [e.g. Streptomyces vinaceusdrappus (FERM BP-4811)] into a medium, primarily culturing the bacterium at 28 deg.C for 4 days by a rotary shaker at 210rpm, transferring the cultured product to a tank, culturing it at 28 deg.C for 115 hours, passing the culture solution through a hydrophobic adsorption resin column to adsorb the product, eluting it and purifying. |
