DERIVES TRIARYLOXYACETYL D'EPIPODOPHYLLOTOXINES, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION COMME MEDICAMENTS ANTICANCEREUX

摘要

Derivatives of general formula (I), wherein R' is methyl or 2-thienyl, R is an acyl group of formula R1OCH2CO, wherein R1 is a phenyl ring ortho-, meta- or para-substituted by one or more substituents X, where X is a formyl, acetyl, cyano or trifluoroacetyl group, and pharmaceutically acceptable salts thereof, are disclosed. A method for preparing said derivatives, their use as a drug, and pharmaceutical compositions containing them, are also disclosed.