发明名称 |
Method for diagnosing amyotrophic lateral sclerosis |
摘要 |
A method and kit are described that are useful in the diagnosis of amyotrophic lateral sclerosis or the evaluation of its progression. According to the method, a purified voltage-sensitive calcium channel complex is contacted with a biological fluid obtained from a person suspected of having, or known to have, amyotrophic lateral sclerosis. The voltage-sensitive calcium channel is of a type that ALS sera selectively reacts with. The reaction takes place for a time and under conditions sufficient for the calcium channel complex and anti-calcium channel complex antibodies that may be present in the biological fluid to form an antigen/antibody complex. The presence or absence of the antigen/antibody complex is then determined.
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申请公布号 |
US5851783(A) |
申请公布日期 |
1998.12.22 |
申请号 |
US19950388179 |
申请日期 |
1995.02.13 |
申请人 |
BAYLOR COLLEGE OF MEDICINE |
发明人 |
APPEL, STANLEY H.;SMITH, R. GLENN;STEFANI, ENRICO |
分类号 |
G01N33/564;G01N33/567;G01N33/68;(IPC1-7):G01N33/543;G01N33/545 |
主分类号 |
G01N33/564 |
代理机构 |
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地址 |
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