| 摘要 |
<p>The present invention includes an improved method to detect and quantitatively assay the amount of DNA damage in large double-stranded DNA templates starting with less than 50 ng of sample DNA. This invention has utility in vivo for quantitating gene-specific DNA damage, measuring DNA repair rates and monitoring efficacy of anti-neoplasia therapy in patients. Additionally, this invention is useful to detect and assess risk due to mutagenic environmental hazard site, and monitor hazard site dynamics and includes a device for accomplishing these objects.</p> |
