2-AMINOINDANS AS SELECTIVE DOPAMINE D3 LIGANDS

摘要

Compounds and their pharmaceutically acceptable salts suitable for treating central nervous system disorders associated with the dopamine D3 receptor activity of formula (I) wherein R1 and R2 are independently H, C1-8 alkyl or C1-8 alkylAryl; X is CH2R3 or NHSO2R4; Y is hydrogen, CH2R3, NHSO2R4, CONR1R2, SO2NR1R2, SO2CH3, halogen, OSO2CF3, SCH3 or OCH3; R3 is NHSO2R4, SO2R4, CONR1R2 or Aryl; and R4 is NR1R2, C1-C8 alkyl, Aryl or C1-C8 alkylAryl.