New phenylamino substd. pyrimido-pyrimidine derivs.

摘要

Substd. 4-phenylamino-pyrimido5,4-dpyrimidines of formula (I) and their tautomers, stereoisomers and salts are new: Ra = H or alkyl; Rb = substd. Ph; Rc = H; F; Cl; Br; I; alkyl; 3-7C cycloalkyl; 3-7C cycloalkyl-1-3C alkyl; aryl; aralkyl; OH; aryloxy; aralkoxy; 1-8C alkoxy (opt. substd. by alkoxycarbonyl, CN, COOH or aminocarbonyl opt. substd. by 1-2 alkyl); 2-8C alkoxy substd. by OH, alkoxy, 2-4C hydroxyalkylamino, amino (opt. mono-substd. by alkyl, alkylcarbonyl, alkylsulphonyl or alkoxycarbonyl or opt. disubstd. by alkyl or by alkyl and alkylcarbonyl, alkylsulphonyl or alkoxycarbonyl) or 5- to 7-membered alkyleneimino opt. substd. by 1-4 alkyl, opt. substd. by oxo on 1 or both C atoms adjacent to the N; 3-8C alkoxy disubstd. by OH or alkoxy; 1-8C alkoxy substd. by 3-7C cycloalkyl (opt. mono- to tetra-substd.); 4-7C cycloalkoxy opt. mono- or disubstd. by OH or opt. mono-substd. by alkoxy, alkoxycarbonyl CN, COOH, aminocarbonyl (opt. mono- or disubstd. by alkyl), 2-4C hydroxyalkylamino or amino (opt. mono-substd. by alkyl, alkylcarbonyl, alkylsulphonyl or alkoxycarbonyl or opt. disubstd. by alkyl or by alkyl and alkylcarbonyl, alkylsulphonyl or alkoxycarbonyl) etc.