发明名称 |
IL-12 INHIBITION OF B1 CELL ACTIVITY |
摘要 |
The invention relates to a method of suppressing B1 cell activity in a host (e.g., mammalian, including human) comprising administering to the host an effective amount of IL-12 that significantly suppresses or inhibits B1 cell activity. In addition, the invention relates to a method of treating a B1 cell disorder in a host, comprising administering to the host an effective therapeutic amount of IL-12. The invention further encompasses a method of screening for substances (e.g., proteins, peptides, small molecules) which enhance or suppress the inhibition of B1 cell activity by IL-12. The invention also relates to a substance identified by the methods of screening for a substance which enhances or suppresses IL-12 inhibition of B1 cell activity. |
申请公布号 |
WO9623521(A1) |
申请公布日期 |
1996.08.08 |
申请号 |
WO1996US01452 |
申请日期 |
1996.02.01 |
申请人 |
MEDICAL COLLEGE OF OHIO;GENETICS INSTITUTE, INC. |
发明人 |
METZGER, DENNIS, W.;VAN CLEAVE, VICTOR, H. |
分类号 |
A61K38/20;G01N33/50 |
主分类号 |
A61K38/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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