NANOERYTHROSOME AS BIOACTIVE AGENT CARRIER

摘要

Carriers for pharmacologic agents comprise nanoerythrosomes, which are vesicles prepared by the extrusion of red blood cell ghosts, the average diameter of these vesicles is 0.1 .mu.m; the daunorubicin was covalently linked to nanoerythrosomes and the cytotoxicity of daunorubicin conjugated to nanoerythrosomes was assessed on P388D1 cell line; the results indicated that the cytotoxicity of conjugated daunorubicin was higher than the free daunorubicin, similar results were observed on CDF1 mice bearing grafted P388D1 leukemia tumors; daunorubicin- nanoerythrosome conjugates had a higher antineoplastic activity than the free bioactive agent.