PYRIDONECARBOXYLIC ACID DERIVATIVES SUBSTITUED BY A BICYCLICAMINO GROUP

摘要

N1-(Halogenocyclopropyl)-substituted pyridonecarboxylic acid derivatives represented by general formula (I), heterocyclic compounds useful as antibacterial agents, wherein X1 represents halo or hydrogen; X2 represents halo; R1 represents hydrogen, hydroxy, thiol, halomethyl, amino, alkyl or alkoxy; R2 represents a group of general formula (II) (wherein R3 and R4 represent each hydrogen or alkyl; and n represents an integer of 1 or 2); A represents nitrogen or a group of general formula (III), (wherein X3 represents halo, cyano, amino, alkyl, halomethyl, alkoxy or halomethoxy); and R represents hydrogen, phenyl, acetoxymethyl, pivaloyloxymethyl, ethoxycarbonyl, choline, dimethylaminoethyl, 5-indanyl, phthalidinyl, 5-alkyl-2-oxo-1, 3-dioxol-4-ylmethyl, 3-acetoxy-2-oxobutyl, alkyl, alkoxymethyl or phenylalkyl.